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PPI-HotSpotDB - A Database of Protein-Protein Interaction Hotspots

This server contains a curated database of residue mutations that are known to disrupt protein-protein interactions.

You entered UniProt code O04197
Data held in the UniProt database for this UniProt code
UniProtUniProt ResNoMutationPubMedNotes
O04197121R->A20927106Loss of interaction with TIFY10A.
O04197301L->A20927106Loss of interaction with TIFY10A.
O04197302Y->A20927106Loss of interaction with TIFY10A.
O04197326R->A20927106Loss of interaction with TIFY10A.
O04197348R->A20927106Loss of interaction with TIFY10A.
O04197351R->A20927106Loss of interaction with TIFY10A.
O04197386Y->A20927106Loss of interaction with TIFY10A.
O04197409R->A20927106Loss of interaction with TIFY10A.
O04197444Y->A20927106Loss of interaction with TIFY10A.
O04197469L->A20927106Loss of interaction with TIFY10A.
O04197496R->A20927106Loss of interaction with TIFY10A.
O0419785R->A20927106Loss of interaction with TIFY10A.
O0419788M->A20927106Loss of interaction with TIFY10A.
O0419789F->A20927106Loss of interaction with TIFY10A.
Data held in the PDB database for this UniProt code
PDB Resolution Chains Residue Mutation UniProt UniProt ResNo PubMed Normalized B-factors SASA 2nd Structure from DSSP Notes
3ogk2.8B,D,F,H,J,L,N,P121R->AO0419712120927106-0.93,-1.02,-0.91,-0.75,-0.98,-0.79,-0.87,-0.946.5,6.5,6.9,7.3,6.7,6.8,6.3,6.7S,S,S,S,S,S,S,SLoss of interaction with TIFY10A.
3ogl3.18B,D,F,H,J,L,N,P121R->AO0419712120927106-1.09,-1.19,-1.21,-0.69,-1.09,-1.14,-1.13,-1.227.0,6.2,6.7,8.0,6.9,6.9,6.4,6.8S,S,S,S,S,S,S,SLoss of interaction with TIFY10A.
3ogm3.34B,D,F,H,J,L,N,P121R->AO0419712120927106-1.10,-1.21,-1.13,-1.00,-1.23,-1.11,-1.05,-1.216.1,6.8,6.3,10.5,6.5,6.4,6.5,6.5S,S,S,S,S,S,S,SLoss of interaction with TIFY10A.
3ogk2.8B,D,F,H,J,L,N,P301L->AO0419730120927106-0.11,-0.21,-0.17,0.10,-0.12,-0.10,-0.11,-0.0211.9,12.1,11.6,5.0,11.5,11.7,11.1,11.5T,T,T,T,T,T,T,TLoss of interaction with TIFY10A.
3ogl3.18B,D,F,H,J,L,N,P301L->AO0419730120927106-0.14,-0.32,-0.32,0.16,-0.31,-0.30,-0.27,-0.1311.5,11.7,11.1,6.7,11.1,11.7,10.7,11.0T,T,T,S,T,T,T,TLoss of interaction with TIFY10A.
3ogm3.34B,D,F,H,J,L,N,P301L->AO0419730120927106-0.27,-0.30,-0.26,-0.46,-0.39,-0.23,-0.34,-0.3012.7,13.0,12.6,8.6,12.7,12.7,12.0,12.8T,T,T,S,T,T,T,TLoss of interaction with TIFY10A.
3ogk2.8B,D,F,H,J,L,N,P302Y->AO04197302209271060.15,0.16,0.21,0.26,0.27,0.31,0.17,0.2038.3,37.7,39.0,34.1,38.4,38.4,38.4,38.1T,T,T,T,T,T,T,TLoss of interaction with TIFY10A.
3ogl3.18B,D,F,H,J,L,N,P302Y->AO04197302209271060.09,0.03,0.22,0.46,0.06,0.08,0.00,0.0640.7,41.1,40.6,33.2,40.9,40.3,41.7,41.1T,T,T,S,T,T,T,TLoss of interaction with TIFY10A.
3ogm3.34B,D,F,H,J,L,N,P302Y->AO04197302209271060.04,-0.07,0.16,0.26,0.09,0.03,0.09,0.0740.1,40.3,39.8,27.5,40.4,39.9,41.3,40.5T,T,T,S,T,T,T,TLoss of interaction with TIFY10A.
3ogk2.8B,D,F,H,J,L,N,P326R->AO0419732620927106-0.23,-0.38,-0.16,0.16,-0.18,-0.04,-0.04,-0.1416.9,16.6,17.0,9.9,16.5,16.7,16.8,17.3E,E,L,L,E,E,E,ELoss of interaction with TIFY10A.
3ogl3.18B,D,F,H,J,L,N,P326R->AO0419732620927106-0.37,-0.45,-0.37,0.25,-0.18,-0.30,-0.14,-0.2617.0,16.8,17.0,10.8,16.3,17.0,16.8,17.4E,E,E,L,E,E,E,ELoss of interaction with TIFY10A.
3ogm3.34B,D,F,H,J,L,N,P326R->AO0419732620927106-0.11,-0.19,-0.10,0.06,0.07,-0.36,0.16,0.0416.9,16.9,16.6,15.1,16.3,16.8,16.9,16.5E,E,E,L,E,E,E,ELoss of interaction with TIFY10A.
3ogk2.8B,D,F,H,J,L,N,P348R->AO0419734820927106-0.57,-0.51,-0.46,-0.54,-0.40,-0.48,-0.52,-0.4823.2,23.7,23.0,22.0,23.4,23.0,23.3,23.1E,E,E,E,E,E,E,ELoss of interaction with TIFY10A.
3ogl3.18B,D,F,H,J,L,N,P348R->AO0419734820927106-0.66,-0.65,-0.62,-0.73,-0.48,-0.53,-0.39,-0.4823.4,23.2,23.7,24.3,23.4,23.2,23.2,22.8E,E,E,E,E,E,E,ELoss of interaction with TIFY10A.
3ogm3.34B,D,F,H,J,L,N,P348R->AO0419734820927106-0.36,-0.53,-0.58,-0.61,-0.44,-0.44,-0.32,-0.4522.8,22.7,22.8,25.2,22.7,22.6,22.4,22.2E,E,E,E,E,E,E,ELoss of interaction with TIFY10A.
3ogk2.8B,D,F,H,J,L,N,P351R->AO04197351209271060.07,-0.01,0.23,2.00,-0.03,0.19,0.13,-0.0053.6,54.4,54.2,22.5,53.8,53.4,54.2,52.6L,L,L,L,L,L,L,LLoss of interaction with TIFY10A.
3ogl3.18B,D,F,H,J,L,N,P351R->AO0419735120927106-0.27,-0.12,-0.09,1.33,-0.25,-0.14,-0.15,-0.1650.9,50.7,51.6,21.3,51.0,51.6,50.0,50.6L,L,L,S,L,L,L,LLoss of interaction with TIFY10A.
3ogm3.34B,D,F,H,J,L,N,P351R->AO04197351209271060.00,0.01,0.01,0.75,-0.23,0.10,-0.12,-0.1051.3,50.8,51.5,18.1,50.9,51.3,50.6,50.4L,L,L,L,L,L,L,LLoss of interaction with TIFY10A.
3ogk2.8B,D,F,H,J,L,N,P386Y->AO0419738620927106-0.24,-0.58,-0.42,-0.60,-0.35,-0.38,-0.39,-0.3522.1,21.8,22.1,22.4,21.6,22.1,21.8,22.2E,E,E,E,E,E,E,ELoss of interaction with TIFY10A.
3ogl3.18B,D,F,H,J,L,N,P386Y->AO0419738620927106-0.45,-0.68,-0.56,-0.67,-0.39,-0.52,-0.32,-0.4820.4,19.9,20.0,20.6,20.2,20.3,19.9,20.3E,E,E,E,E,E,E,ELoss of interaction with TIFY10A.
3ogm3.34B,D,F,H,J,L,N,P386Y->AO0419738620927106-0.24,-0.26,-0.34,0.65,-0.28,-0.24,-0.04,-0.2721.3,21.0,21.2,20.2,21.5,21.2,21.1,21.4E,E,E,E,E,E,E,ELoss of interaction with TIFY10A.
3ogk2.8B,D,F,H,J,L,N,P409R->AO0419740920927106-0.53,-0.51,-0.47,-0.69,-0.41,-0.37,-0.32,-0.3917.0,17.3,17.3,18.8,17.3,16.5,17.4,16.9E,E,E,E,E,E,E,ELoss of interaction with TIFY10A.
3ogl3.18B,D,F,H,J,L,N,P409R->AO0419740920927106-0.60,-0.47,-0.51,-0.58,-0.47,-0.41,-0.34,-0.2418.9,18.4,18.5,21.0,18.9,17.7,18.8,18.7E,E,E,E,E,E,E,ELoss of interaction with TIFY10A.
3ogm3.34B,D,F,H,J,L,N,P409R->AO0419740920927106-0.42,-0.57,-0.45,-0.59,-0.40,-0.50,-0.28,-0.5118.6,18.8,18.8,20.2,18.6,18.0,18.4,18.6E,E,E,E,E,E,E,ELoss of interaction with TIFY10A.
3ogk2.8B,D,F,H,J,L,N,P444Y->AO0419744420927106-0.13,-0.21,-0.13,-0.61,-0.27,-0.24,-0.25,-0.2517.1,16.9,16.6,14.4,16.6,16.7,17.4,17.3E,E,E,E,E,E,E,ELoss of interaction with TIFY10A.
3ogl3.18B,D,F,H,J,L,N,P444Y->AO0419744420927106-0.32,-0.28,-0.28,-0.46,-0.35,-0.20,-0.40,-0.2117.6,17.4,17.0,16.6,17.0,17.2,18.0,17.0E,E,E,E,E,E,E,ELoss of interaction with TIFY10A.
3ogm3.34B,D,F,H,J,L,N,P444Y->AO0419744420927106-0.38,-0.35,-0.39,-0.76,-0.45,-0.28,-0.36,-0.2917.6,17.6,17.0,11.2,17.7,18.1,18.1,17.8E,E,E,L,E,E,E,ELoss of interaction with TIFY10A.
3ogk2.8B,D,F,H,J,L,N,P469L->AO0419746920927106-0.72,-0.66,-0.67,-0.43,-0.64,-0.57,-0.74,-0.4215.4,15.1,15.5,16.0,15.0,15.4,15.2,15.3E,E,E,E,E,E,E,ELoss of interaction with TIFY10A.
3ogl3.18B,D,F,H,J,L,N,P469L->AO0419746920927106-0.57,-0.66,-0.71,-0.79,-0.58,-0.53,-0.57,-0.3416.7,16.8,16.8,20.1,16.9,17.0,16.9,16.7E,E,E,E,E,E,E,ELoss of interaction with TIFY10A.
3ogm3.34B,D,F,H,J,L,N,P469L->AO0419746920927106-0.56,-0.60,-0.79,-0.54,-0.55,-0.58,-0.61,-0.4917.1,17.2,17.1,20.0,17.0,16.8,17.0,17.1E,E,E,E,E,E,E,ELoss of interaction with TIFY10A.
3ogk2.8B,D,F,H,J,L,N,P496R->AO04197496209271060.12,0.06,0.08,-0.52,0.14,0.27,0.02,0.0828.6,29.5,28.8,29.8,29.3,29.7,29.0,29.2E,E,E,E,E,E,E,ELoss of interaction with TIFY10A.
3ogl3.18B,D,F,H,J,L,N,P496R->AO04197496209271060.16,-0.18,0.02,-0.65,0.04,0.16,-0.09,-0.0432.5,32.6,32.9,26.3,32.1,32.5,32.4,33.0E,E,E,E,E,E,E,ELoss of interaction with TIFY10A.
3ogm3.34B,D,F,H,J,L,N,P496R->AO04197496209271060.17,0.02,-0.23,-0.10,-0.06,0.16,-0.12,-0.0733.7,34.2,33.8,35.5,33.4,33.6,33.6,33.7E,E,E,E,E,E,E,ELoss of interaction with TIFY10A.
3ogk2.8B,D,F,H,J,L,N,P85R->AO041978520927106-0.73,-0.61,-0.64,-0.45,-0.70,-0.72,-0.72,-0.6316.8,16.7,17.0,24.5,16.9,16.3,17.2,16.7G,G,G,G,G,G,G,GLoss of interaction with TIFY10A.
3ogl3.18B,D,F,H,J,L,N,P85R->AO041978520927106-0.73,-0.73,-0.63,-0.10,-0.76,-0.77,-0.86,-0.6917.0,17.0,17.1,23.0,17.1,16.6,17.2,16.9G,G,G,G,G,G,G,GLoss of interaction with TIFY10A.
3ogm3.34B,D,F,H,J,L,N,P85R->AO041978520927106-0.72,-0.78,-0.58,-0.97,-0.77,-0.64,-0.90,-0.6918.1,17.9,17.9,24.1,18.2,17.9,18.2,18.0G,G,G,G,G,G,G,GLoss of interaction with TIFY10A.
3ogk2.8B,D,F,H,J,L,N,P88M->AO041978820927106-0.34,-0.31,-0.59,0.73,-0.61,-0.46,-0.42,-0.6534.4,34.1,33.6,35.3,34.2,34.2,33.5,33.7G,G,G,G,G,G,G,GLoss of interaction with TIFY10A.
3ogl3.18B,D,F,H,J,L,N,P88M->AO041978820927106-0.69,-0.65,-0.60,0.76,-0.73,-0.72,-0.47,-0.7231.3,31.9,31.7,33.3,31.8,31.3,32.0,31.3G,G,G,G,G,G,G,GLoss of interaction with TIFY10A.
3ogm3.34B,D,F,H,J,L,N,P88M->AO041978820927106-0.79,-0.68,-0.85,-0.58,-0.79,-0.77,-0.84,-0.8927.3,28.2,28.5,39.3,26.8,28.0,27.4,28.1G,G,G,G,G,G,G,GLoss of interaction with TIFY10A.
3ogk2.8B,D,F,H,J,L,N,P89F->AO041978920927106-0.34,-0.35,-0.38,0.07,-0.37,-0.27,-0.20,-0.5350.0,50.2,51.4,52.0,50.6,50.2,49.4,49.5G,G,G,G,G,G,G,GLoss of interaction with TIFY10A.
3ogl3.18B,D,F,H,J,L,N,P89F->AO041978920927106-0.62,-0.75,-0.66,0.55,-0.61,-0.59,-0.56,-0.6545.5,46.1,47.0,57.2,46.2,45.6,44.5,45.2G,G,G,G,G,G,G,GLoss of interaction with TIFY10A.
3ogm3.34B,D,F,H,J,L,N,P89F->AO041978920927106-0.60,-0.43,-0.45,-0.27,-0.52,-0.56,-0.41,-0.4245.6,45.9,46.1,55.8,46.7,45.4,45.5,46.2G,G,G,G,G,G,G,GLoss of interaction with TIFY10A.
There is the following binding data for these residues
PDBChainResidueWild TypeUniProt IDUniProt ResNoBinding Partner
3ogkB121ARGO04197121Binding with ligand PO4
3ogkB301LEUO04197301Binding with 3ogk CHAIN Q 209 LEU
3ogkB302TYRO04197302Binding with 3ogk CHAIN Q 208 SER, binding with 3ogk CHAIN Q 212 PHE
3ogkB326ARGO04197326Binding with 3ogk CHAIN Q 212 PHE, binding with 3ogk CHAIN Q 209 LEU
3ogkB348ARGO04197348Binding with ligand OGK
3ogkB351ARGO04197351Binding with 3ogk CHAIN Q 205 ARG, binding with 3ogk CHAIN Q 209 LEU
3ogkB386TYRO04197386Binding with ligand OGK
3ogkB409ARGO04197409Binding with ligand PO4, binding with ligand OGK
3ogkB444TYRO04197444Binding with ligand OGK
3ogkB469LEUO04197469Binding with ligand OGK
3ogkB496ARGO04197496Binding with ligand OGK
3ogkB85ARGO0419785Binding with ligand PO4, binding with ligand OGK
3ogkB88METO0419788Binding with ligand PO4, binding with 3ogk CHAIN Q 206 ARG, binding with 3ogk CHAIN Q 207 ALA
3ogkB89PHEO0419789Binding with 3ogk CHAIN Q 206 ARG, binding with ligand OGK
3ogkD121ARGO04197121Binding with ligand PO4
3ogkD301LEUO04197301Binding with 3ogk CHAIN R 209 LEU
3ogkD302TYRO04197302Binding with 3ogk CHAIN R 208 SER, binding with 3ogk CHAIN R 212 PHE
3ogkD326ARGO04197326Binding with 3ogk CHAIN R 212 PHE, binding with 3ogk CHAIN R 209 LEU
3ogkD348ARGO04197348Binding with ligand OGK
3ogkD351ARGO04197351Binding with 3ogk CHAIN R 209 LEU, binding with 3ogk CHAIN R 205 ARG
3ogkD386TYRO04197386Binding with ligand OGK
3ogkD409ARGO04197409Binding with ligand PO4, binding with ligand OGK
3ogkD444TYRO04197444Binding with ligand OGK
3ogkD469LEUO04197469Binding with ligand OGK
3ogkD496ARGO04197496Binding with ligand OGK
3ogkD85ARGO0419785Binding with ligand PO4, binding with ligand OGK
3ogkD88METO0419788Binding with 3ogk CHAIN R 207 ALA, binding with 3ogk CHAIN R 206 ARG, binding with ligand PO4
3ogkD89PHEO0419789Binding with 3ogk CHAIN R 206 ARG, binding with ligand OGK
3ogkF121ARGO04197121Binding with ligand PO4
3ogkF301LEUO04197301Binding with 3ogk CHAIN S 209 LEU
3ogkF302TYRO04197302Binding with 3ogk CHAIN S 208 SER, binding with 3ogk CHAIN S 212 PHE
3ogkF326ARGO04197326Binding with 3ogk CHAIN S 212 PHE, binding with 3ogk CHAIN S 209 LEU
3ogkF348ARGO04197348Binding with ligand OGK
3ogkF351ARGO04197351Binding with 3ogk CHAIN S 205 ARG, binding with 3ogk CHAIN S 209 LEU
3ogkF386TYRO04197386Binding with ligand OGK
3ogkF409ARGO04197409Binding with ligand PO4, binding with ligand OGK
3ogkF444TYRO04197444Binding with ligand OGK
3ogkF469LEUO04197469Binding with ligand OGK
3ogkF496ARGO04197496Binding with ligand OGK
3ogkF85ARGO0419785Binding with ligand PO4, binding with ligand OGK
3ogkF88METO0419788Binding with 3ogk CHAIN S 206 ARG, binding with 3ogk CHAIN S 207 ALA, binding with ligand PO4
3ogkF89PHEO0419789Binding with 3ogk CHAIN S 206 ARG, binding with ligand OGK
3ogkH121ARGO04197121Binding with ligand PO4
3ogkH348ARGO04197348Binding with ligand OGK
3ogkH386TYRO04197386Binding with ligand OGK
3ogkH409ARGO04197409Binding with ligand PO4, binding with ligand OGK
3ogkH444TYRO04197444Binding with ligand OGK
3ogkH469LEUO04197469Binding with ligand OGK
3ogkH496ARGO04197496Binding with ligand OGK
3ogkH85ARGO0419785Binding with ligand PO4, binding with ligand OGK
3ogkH88METO0419788Binding with ligand PO4
3ogkH89PHEO0419789Binding with ligand OGK
3ogkJ121ARGO04197121Binding with ligand PO4
3ogkJ301LEUO04197301Binding with 3ogk CHAIN U 209 LEU
3ogkJ302TYRO04197302Binding with 3ogk CHAIN U 208 SER, binding with 3ogk CHAIN U 212 PHE
3ogkJ326ARGO04197326Binding with 3ogk CHAIN U 209 LEU, binding with 3ogk CHAIN U 212 PHE
3ogkJ348ARGO04197348Binding with 3ogk CHAIN U 206 ARG, binding with ligand OGK
3ogkJ351ARGO04197351Binding with 3ogk CHAIN U 205 ARG, binding with 3ogk CHAIN U 209 LEU
3ogkJ386TYRO04197386Binding with ligand OGK
3ogkJ409ARGO04197409Binding with ligand PO4, binding with ligand OGK
3ogkJ469LEUO04197469Binding with ligand OGK
3ogkJ496ARGO04197496Binding with ligand OGK
3ogkJ85ARGO0419785Binding with ligand PO4, binding with ligand OGK
3ogkJ88METO0419788Binding with 3ogk CHAIN U 207 ALA, binding with 3ogk CHAIN U 206 ARG, binding with ligand PO4
3ogkJ89PHEO0419789Binding with 3ogk CHAIN U 206 ARG, binding with 3ogk CHAIN U 205 ARG, binding with ligand OGK
3ogkL121ARGO04197121Binding with ligand PO4
3ogkL302TYRO04197302Binding with 3ogk CHAIN V 208 SER, binding with 3ogk CHAIN V 212 PHE
3ogkL326ARGO04197326Binding with 3ogk CHAIN V 212 PHE, binding with 3ogk CHAIN V 209 LEU
3ogkL348ARGO04197348Binding with ligand OGK
3ogkL351ARGO04197351Binding with 3ogk CHAIN V 209 LEU
3ogkL386TYRO04197386Binding with ligand OGK
3ogkL409ARGO04197409Binding with ligand PO4, binding with ligand OGK
3ogkL444TYRO04197444Binding with ligand OGK
3ogkL469LEUO04197469Binding with ligand OGK
3ogkL496ARGO04197496Binding with ligand OGK
3ogkL85ARGO0419785Binding with ligand PO4, binding with ligand OGK
3ogkL88METO0419788Binding with 3ogk CHAIN V 207 ALA, binding with 3ogk CHAIN V 206 ARG, binding with ligand PO4
3ogkL89PHEO0419789Binding with 3ogk CHAIN V 206 ARG, binding with ligand OGK, binding with 3ogk CHAIN V 205 ARG
3ogkN121ARGO04197121Binding with ligand PO4
3ogkN302TYRO04197302Binding with 3ogk CHAIN W 212 PHE, binding with 3ogk CHAIN W 208 SER
3ogkN326ARGO04197326Binding with 3ogk CHAIN W 209 LEU
3ogkN348ARGO04197348Binding with ligand OGK
3ogkN351ARGO04197351Binding with 3ogk CHAIN W 209 LEU
3ogkN386TYRO04197386Binding with ligand OGK
3ogkN409ARGO04197409Binding with ligand PO4, binding with ligand OGK
3ogkN444TYRO04197444Binding with ligand OGK
3ogkN469LEUO04197469Binding with ligand OGK
3ogkN496ARGO04197496Binding with ligand OGK
3ogkN85ARGO0419785Binding with ligand PO4, binding with ligand OGK
3ogkN88METO0419788Binding with ligand PO4, binding with 3ogk CHAIN W 206 ARG, binding with 3ogk CHAIN W 207 ALA
3ogkN89PHEO0419789Binding with 3ogk CHAIN W 206 ARG, binding with ligand OGK
3ogkP121ARGO04197121Binding with ligand PO4
3ogkP301LEUO04197301Binding with 3ogk CHAIN X 209 LEU
3ogkP302TYRO04197302Binding with 3ogk CHAIN X 208 SER, binding with 3ogk CHAIN X 212 PHE
3ogkP326ARGO04197326Binding with 3ogk CHAIN X 209 LEU, binding with 3ogk CHAIN X 212 PHE
3ogkP348ARGO04197348Binding with 3ogk CHAIN X 206 ARG, binding with ligand OGK
3ogkP351ARGO04197351Binding with 3ogk CHAIN X 209 LEU, binding with 3ogk CHAIN X 205 ARG
3ogkP386TYRO04197386Binding with ligand OGK
3ogkP409ARGO04197409Binding with ligand PO4, binding with ligand OGK
3ogkP444TYRO04197444Binding with ligand OGK
3ogkP469LEUO04197469Binding with ligand OGK
3ogkP496ARGO04197496Binding with ligand OGK
3ogkP85ARGO0419785Binding with ligand PO4, binding with ligand OGK
3ogkP88METO0419788Binding with ligand PO4, binding with 3ogk CHAIN X 206 ARG, binding with 3ogk CHAIN X 207 ALA
3ogkP89PHEO0419789Binding with 3ogk CHAIN X 206 ARG, binding with ligand OGK
3oglB121ARGO04197121Binding with ligand PO4
3oglB301LEUO04197301Binding with 3ogl CHAIN Q 209 LEU
3oglB302TYRO04197302Binding with 3ogl CHAIN Q 208 SER, binding with 3ogl CHAIN Q 212 PHE
3oglB326ARGO04197326Binding with 3ogl CHAIN Q 216 ARG, binding with 3ogl CHAIN Q 212 PHE
3oglB348ARGO04197348Binding with 3ogl CHAIN Q 206 ARG, binding with ligand 7JA
3oglB351ARGO04197351Binding with 3ogl CHAIN Q 203 ILE, binding with 3ogl CHAIN Q 209 LEU, binding with 3ogl CHAIN Q 205 ARG
3oglB386TYRO04197386Binding with ligand 7JA
3oglB409ARGO04197409Binding with ligand PO4, binding with ligand 7JA
3oglB444TYRO04197444Binding with ligand 7JA
3oglB469LEUO04197469Binding with ligand 7JA
3oglB496ARGO04197496Binding with 3ogl CHAIN Q 201 LEU, binding with ligand 7JA, binding with 3ogl CHAIN Q 202 PRO
3oglB85ARGO0419785Binding with ligand PO4, binding with ligand 7JA
3oglB88METO0419788Binding with ligand PO4, binding with 3ogl CHAIN Q 206 ARG, binding with 3ogl CHAIN Q 207 ALA
3oglB89PHEO0419789Binding with 3ogl CHAIN Q 206 ARG, binding with ligand 7JA, binding with 3ogl CHAIN Q 204 ALA, binding with 3ogl CHAIN Q 205 ARG
3oglD121ARGO04197121Binding with ligand PO4
3oglD301LEUO04197301Binding with 3ogl CHAIN R 209 LEU
3oglD302TYRO04197302Binding with 3ogl CHAIN R 212 PHE, binding with 3ogl CHAIN R 208 SER
3oglD326ARGO04197326Binding with 3ogl CHAIN R 212 PHE
3oglD348ARGO04197348Binding with 3ogl CHAIN R 206 ARG, binding with ligand 7JA
3oglD351ARGO04197351Binding with 3ogl CHAIN R 209 LEU, binding with 3ogl CHAIN R 205 ARG, binding with 3ogl CHAIN R 203 ILE
3oglD386TYRO04197386Binding with ligand 7JA
3oglD409ARGO04197409Binding with ligand PO4, binding with ligand 7JA
3oglD444TYRO04197444Binding with ligand 7JA
3oglD469LEUO04197469Binding with ligand 7JA
3oglD496ARGO04197496Binding with 3ogl CHAIN R 201 LEU, binding with 3ogl CHAIN R 202 PRO, binding with ligand 7JA
3oglD85ARGO0419785Binding with ligand PO4, binding with ligand 7JA
3oglD88METO0419788Binding with ligand PO4, binding with 3ogl CHAIN R 206 ARG, binding with 3ogl CHAIN R 207 ALA
3oglD89PHEO0419789Binding with 3ogl CHAIN R 204 ALA, binding with 3ogl CHAIN R 205 ARG, binding with 3ogl CHAIN R 206 ARG, binding with ligand 7JA
3oglF121ARGO04197121Binding with ligand PO4
3oglF301LEUO04197301Binding with 3ogl CHAIN S 209 LEU
3oglF302TYRO04197302Binding with 3ogl CHAIN S 208 SER, binding with 3ogl CHAIN S 212 PHE
3oglF326ARGO04197326Binding with 3ogl CHAIN S 212 PHE
3oglF348ARGO04197348Binding with 3ogl CHAIN S 206 ARG, binding with ligand 7JA
3oglF351ARGO04197351Binding with 3ogl CHAIN S 205 ARG, binding with 3ogl CHAIN S 209 LEU, binding with 3ogl CHAIN S 203 ILE
3oglF386TYRO04197386Binding with ligand 7JA
3oglF409ARGO04197409Binding with ligand PO4, binding with ligand 7JA
3oglF444TYRO04197444Binding with ligand 7JA
3oglF469LEUO04197469Binding with ligand 7JA
3oglF496ARGO04197496Binding with 3ogl CHAIN S 201 LEU, binding with ligand 7JA, binding with 3ogl CHAIN S 202 PRO
3oglF85ARGO0419785Binding with ligand PO4, binding with ligand 7JA
3oglF88METO0419788Binding with 3ogl CHAIN S 206 ARG, binding with ligand PO4, binding with 3ogl CHAIN S 207 ALA
3oglF89PHEO0419789Binding with 3ogl CHAIN S 204 ALA, binding with 3ogl CHAIN S 205 ARG, binding with 3ogl CHAIN S 206 ARG, binding with ligand 7JA
3oglH121ARGO04197121Binding with ligand PO4
3oglH348ARGO04197348Binding with ligand 7JA
3oglH386TYRO04197386Binding with ligand 7JA
3oglH409ARGO04197409Binding with ligand PO4, binding with ligand 7JA
3oglH469LEUO04197469Binding with ligand 7JA
3oglH496ARGO04197496Binding with ligand 7JA
3oglH85ARGO0419785Binding with ligand PO4, binding with ligand 7JA
3oglH88METO0419788Binding with ligand PO4
3oglH89PHEO0419789Binding with ligand 7JA
3oglJ121ARGO04197121Binding with ligand PO4
3oglJ301LEUO04197301Binding with 3ogl CHAIN U 209 LEU
3oglJ302TYRO04197302Binding with 3ogl CHAIN U 208 SER, binding with 3ogl CHAIN U 212 PHE
3oglJ326ARGO04197326Binding with 3ogl CHAIN U 209 LEU, binding with 3ogl CHAIN U 212 PHE
3oglJ348ARGO04197348Binding with 3ogl CHAIN U 206 ARG, binding with ligand 7JA
3oglJ351ARGO04197351Binding with 3ogl CHAIN U 209 LEU, binding with 3ogl CHAIN U 203 ILE, binding with 3ogl CHAIN U 205 ARG
3oglJ386TYRO04197386Binding with ligand 7JA
3oglJ409ARGO04197409Binding with ligand PO4, binding with ligand 7JA
3oglJ444TYRO04197444Binding with ligand 7JA
3oglJ469LEUO04197469Binding with ligand 7JA
3oglJ496ARGO04197496Binding with 3ogl CHAIN U 201 LEU, binding with 3ogl CHAIN U 202 PRO, binding with ligand 7JA
3oglJ85ARGO0419785Binding with ligand PO4, binding with ligand 7JA
3oglJ88METO0419788Binding with 3ogl CHAIN U 206 ARG, binding with ligand PO4, binding with 3ogl CHAIN U 207 ALA
3oglJ89PHEO0419789Binding with 3ogl CHAIN U 206 ARG, binding with 3ogl CHAIN U 204 ALA, binding with ligand 7JA, binding with 3ogl CHAIN U 205 ARG
3oglL121ARGO04197121Binding with ligand PO4
3oglL301LEUO04197301Binding with 3ogl CHAIN V 209 LEU
3oglL302TYRO04197302Binding with 3ogl CHAIN V 208 SER, binding with 3ogl CHAIN V 212 PHE
3oglL326ARGO04197326Binding with 3ogl CHAIN V 212 PHE, binding with 3ogl CHAIN V 209 LEU
3oglL348ARGO04197348Binding with 3ogl CHAIN V 206 ARG, binding with ligand 7JA
3oglL351ARGO04197351Binding with 3ogl CHAIN V 205 ARG, binding with 3ogl CHAIN V 203 ILE, binding with 3ogl CHAIN V 209 LEU
3oglL386TYRO04197386Binding with ligand 7JA
3oglL409ARGO04197409Binding with ligand PO4, binding with ligand 7JA
3oglL444TYRO04197444Binding with ligand 7JA
3oglL469LEUO04197469Binding with ligand 7JA
3oglL496ARGO04197496Binding with ligand 7JA, binding with 3ogl CHAIN V 201 LEU, binding with 3ogl CHAIN V 202 PRO
3oglL85ARGO0419785Binding with ligand PO4, binding with ligand 7JA
3oglL88METO0419788Binding with 3ogl CHAIN V 206 ARG, binding with ligand PO4, binding with 3ogl CHAIN V 207 ALA
3oglL89PHEO0419789Binding with 3ogl CHAIN V 206 ARG, binding with 3ogl CHAIN V 205 ARG, binding with ligand 7JA, binding with 3ogl CHAIN V 204 ALA
3oglN121ARGO04197121Binding with ligand PO4
3oglN301LEUO04197301Binding with 3ogl CHAIN W 209 LEU
3oglN302TYRO04197302Binding with 3ogl CHAIN W 208 SER, binding with 3ogl CHAIN W 212 PHE
3oglN326ARGO04197326Binding with 3ogl CHAIN W 212 PHE
3oglN348ARGO04197348Binding with ligand 7JA, binding with 3ogl CHAIN W 206 ARG
3oglN351ARGO04197351Binding with 3ogl CHAIN W 205 ARG, binding with 3ogl CHAIN W 203 ILE, binding with 3ogl CHAIN W 209 LEU
3oglN386TYRO04197386Binding with ligand 7JA
3oglN409ARGO04197409Binding with ligand PO4, binding with ligand 7JA
3oglN444TYRO04197444Binding with ligand 7JA
3oglN469LEUO04197469Binding with ligand 7JA
3oglN496ARGO04197496Binding with 3ogl CHAIN W 202 PRO, binding with ligand 7JA, binding with 3ogl CHAIN W 201 LEU
3oglN85ARGO0419785Binding with ligand PO4, binding with ligand 7JA
3oglN88METO0419788Binding with ligand PO4, binding with 3ogl CHAIN W 207 ALA, binding with 3ogl CHAIN W 206 ARG
3oglN89PHEO0419789Binding with 3ogl CHAIN W 205 ARG, binding with 3ogl CHAIN W 204 ALA, binding with ligand 7JA, binding with 3ogl CHAIN W 206 ARG
3oglP121ARGO04197121Binding with ligand PO4
3oglP301LEUO04197301Binding with 3ogl CHAIN X 209 LEU
3oglP302TYRO04197302Binding with 3ogl CHAIN X 208 SER, binding with 3ogl CHAIN X 212 PHE
3oglP326ARGO04197326Binding with 3ogl CHAIN X 216 ARG, binding with 3ogl CHAIN X 212 PHE
3oglP348ARGO04197348Binding with 3ogl CHAIN X 206 ARG, binding with ligand 7JA
3oglP351ARGO04197351Binding with 3ogl CHAIN X 203 ILE, binding with 3ogl CHAIN X 209 LEU, binding with 3ogl CHAIN X 205 ARG
3oglP386TYRO04197386Binding with ligand 7JA
3oglP409ARGO04197409Binding with ligand PO4, binding with ligand 7JA
3oglP444TYRO04197444Binding with ligand 7JA
3oglP469LEUO04197469Binding with ligand 7JA
3oglP496ARGO04197496Binding with 3ogl CHAIN X 202 PRO, binding with 3ogl CHAIN X 201 LEU, binding with ligand 7JA
3oglP85ARGO0419785Binding with ligand PO4, binding with ligand 7JA
3oglP88METO0419788Binding with 3ogl CHAIN X 206 ARG, binding with ligand PO4, binding with 3ogl CHAIN X 207 ALA
3oglP89PHEO0419789Binding with 3ogl CHAIN X 206 ARG, binding with 3ogl CHAIN X 204 ALA, binding with ligand 7JA, binding with 3ogl CHAIN X 205 ARG
3ogmB121ARGO04197121Binding with ligand PO4
3ogmB301LEUO04197301Binding with 3ogm CHAIN Q 209 LEU
3ogmB302TYRO04197302Binding with 3ogm CHAIN Q 208 SER, binding with 3ogm CHAIN Q 212 PHE
3ogmB326ARGO04197326Binding with 3ogm CHAIN Q 216 ARG, binding with 3ogm CHAIN Q 212 PHE
3ogmB348ARGO04197348Binding with ligand OGK
3ogmB351ARGO04197351Binding with 3ogm CHAIN Q 203 ILE, binding with 3ogm CHAIN Q 205 ARG, binding with 3ogm CHAIN Q 209 LEU
3ogmB386TYRO04197386Binding with ligand OGK
3ogmB409ARGO04197409Binding with ligand PO4, binding with ligand OGK
3ogmB444TYRO04197444Binding with ligand OGK
3ogmB469LEUO04197469Binding with ligand OGK
3ogmB496ARGO04197496Binding with 3ogm CHAIN Q 202 PRO, binding with ligand OGK, binding with 3ogm CHAIN Q 201 LEU
3ogmB85ARGO0419785Binding with ligand PO4, binding with ligand OGK
3ogmB88METO0419788Binding with 3ogm CHAIN Q 207 ALA, binding with 3ogm CHAIN Q 206 ARG
3ogmB89PHEO0419789Binding with 3ogm CHAIN Q 204 ALA, binding with 3ogm CHAIN Q 205 ARG, binding with ligand OGK, binding with 3ogm CHAIN Q 206 ARG
3ogmD121ARGO04197121Binding with ligand PO4
3ogmD301LEUO04197301Binding with 3ogm CHAIN R 209 LEU
3ogmD302TYRO04197302Binding with 3ogm CHAIN R 212 PHE, binding with 3ogm CHAIN R 208 SER
3ogmD326ARGO04197326Binding with 3ogm CHAIN R 212 PHE
3ogmD348ARGO04197348Binding with ligand OGK
3ogmD351ARGO04197351Binding with 3ogm CHAIN R 209 LEU, binding with 3ogm CHAIN R 205 ARG, binding with 3ogm CHAIN R 203 ILE
3ogmD386TYRO04197386Binding with ligand OGK
3ogmD409ARGO04197409Binding with ligand PO4, binding with ligand OGK
3ogmD444TYRO04197444Binding with ligand OGK
3ogmD469LEUO04197469Binding with ligand OGK
3ogmD496ARGO04197496Binding with 3ogm CHAIN R 201 LEU, binding with 3ogm CHAIN R 202 PRO, binding with ligand OGK, binding with 3ogm CHAIN R 204 ALA
3ogmD85ARGO0419785Binding with ligand PO4, binding with ligand OGK
3ogmD88METO0419788Binding with 3ogm CHAIN R 206 ARG, binding with 3ogm CHAIN R 207 ALA
3ogmD89PHEO0419789Binding with 3ogm CHAIN R 206 ARG, binding with 3ogm CHAIN R 205 ARG, binding with ligand OGK, binding with 3ogm CHAIN R 204 ALA
3ogmF121ARGO04197121Binding with ligand PO4
3ogmF301LEUO04197301Binding with 3ogm CHAIN S 209 LEU
3ogmF302TYRO04197302Binding with 3ogm CHAIN S 208 SER, binding with 3ogm CHAIN S 212 PHE
3ogmF326ARGO04197326Binding with 3ogm CHAIN S 212 PHE, binding with 3ogm CHAIN S 216 ARG
3ogmF348ARGO04197348Binding with ligand OGK
3ogmF351ARGO04197351Binding with 3ogm CHAIN S 203 ILE, binding with 3ogm CHAIN S 209 LEU, binding with 3ogm CHAIN S 205 ARG
3ogmF386TYRO04197386Binding with ligand OGK
3ogmF409ARGO04197409Binding with ligand PO4, binding with ligand OGK
3ogmF444TYRO04197444Binding with ligand OGK
3ogmF469LEUO04197469Binding with ligand OGK
3ogmF496ARGO04197496Binding with 3ogm CHAIN S 201 LEU, binding with 3ogm CHAIN S 202 PRO, binding with ligand OGK, binding with 3ogm CHAIN S 204 ALA
3ogmF85ARGO0419785Binding with ligand PO4, binding with ligand OGK
3ogmF88METO0419788Binding with 3ogm CHAIN S 206 ARG, binding with 3ogm CHAIN S 207 ALA
3ogmF89PHEO0419789Binding with ligand OGK, binding with 3ogm CHAIN S 206 ARG, binding with 3ogm CHAIN S 205 ARG
3ogmH121ARGO04197121Binding with ligand PO4
3ogmH348ARGO04197348Binding with ligand OGK
3ogmH386TYRO04197386Binding with ligand OGK
3ogmH409ARGO04197409Binding with ligand PO4, binding with ligand OGK
3ogmH469LEUO04197469Binding with ligand OGK
3ogmH496ARGO04197496Binding with ligand OGK
3ogmH85ARGO0419785Binding with ligand PO4, binding with ligand OGK
3ogmH88METO0419788Binding with ligand PO4
3ogmH89PHEO0419789Binding with ligand OGK
3ogmJ121ARGO04197121Binding with ligand PO4
3ogmJ301LEUO04197301Binding with 3ogm CHAIN U 209 LEU
3ogmJ302TYRO04197302Binding with 3ogm CHAIN U 208 SER, binding with 3ogm CHAIN U 212 PHE
3ogmJ326ARGO04197326Binding with 3ogm CHAIN U 212 PHE
3ogmJ348ARGO04197348Binding with 3ogm CHAIN U 206 ARG, binding with ligand OGK
3ogmJ351ARGO04197351Binding with 3ogm CHAIN U 205 ARG, binding with 3ogm CHAIN U 203 ILE, binding with 3ogm CHAIN U 209 LEU
3ogmJ386TYRO04197386Binding with ligand OGK
3ogmJ409ARGO04197409Binding with ligand PO4, binding with ligand OGK
3ogmJ444TYRO04197444Binding with ligand OGK
3ogmJ469LEUO04197469Binding with ligand OGK
3ogmJ496ARGO04197496Binding with 3ogm CHAIN U 204 ALA, binding with 3ogm CHAIN U 201 LEU, binding with 3ogm CHAIN U 202 PRO, binding with ligand OGK
3ogmJ85ARGO0419785Binding with ligand PO4, binding with ligand OGK
3ogmJ88METO0419788Binding with 3ogm CHAIN U 206 ARG, binding with 3ogm CHAIN U 207 ALA
3ogmJ89PHEO0419789Binding with 3ogm CHAIN U 206 ARG, binding with 3ogm CHAIN U 204 ALA, binding with 3ogm CHAIN U 205 ARG, binding with ligand OGK
3ogmL121ARGO04197121Binding with ligand PO4
3ogmL301LEUO04197301Binding with 3ogm CHAIN V 209 LEU
3ogmL302TYRO04197302Binding with 3ogm CHAIN V 212 PHE, binding with 3ogm CHAIN V 208 SER
3ogmL326ARGO04197326Binding with 3ogm CHAIN V 212 PHE
3ogmL348ARGO04197348Binding with ligand OGK
3ogmL351ARGO04197351Binding with 3ogm CHAIN V 209 LEU, binding with 3ogm CHAIN V 205 ARG, binding with 3ogm CHAIN V 203 ILE
3ogmL386TYRO04197386Binding with ligand OGK
3ogmL409ARGO04197409Binding with ligand PO4, binding with ligand OGK
3ogmL444TYRO04197444Binding with ligand OGK
3ogmL469LEUO04197469Binding with ligand OGK
3ogmL496ARGO04197496Binding with 3ogm CHAIN V 204 ALA, binding with ligand OGK, binding with 3ogm CHAIN V 201 LEU, binding with 3ogm CHAIN V 202 PRO
3ogmL85ARGO0419785Binding with ligand PO4, binding with ligand OGK
3ogmL88METO0419788Binding with 3ogm CHAIN V 207 ALA, binding with 3ogm CHAIN V 206 ARG
3ogmL89PHEO0419789Binding with 3ogm CHAIN V 204 ALA, binding with 3ogm CHAIN V 206 ARG, binding with 3ogm CHAIN V 205 ARG, binding with ligand OGK
3ogmN121ARGO04197121Binding with ligand PO4
3ogmN302TYRO04197302Binding with 3ogm CHAIN W 208 SER, binding with 3ogm CHAIN W 212 PHE
3ogmN348ARGO04197348Binding with ligand OGK
3ogmN351ARGO04197351Binding with 3ogm CHAIN W 203 ILE, binding with 3ogm CHAIN W 209 LEU
3ogmN386TYRO04197386Binding with ligand OGK
3ogmN409ARGO04197409Binding with ligand PO4, binding with ligand OGK
3ogmN444TYRO04197444Binding with ligand OGK
3ogmN469LEUO04197469Binding with ligand OGK
3ogmN496ARGO04197496Binding with 3ogm CHAIN W 201 LEU, binding with ligand OGK, binding with 3ogm CHAIN W 202 PRO
3ogmN85ARGO0419785Binding with ligand PO4, binding with ligand OGK
3ogmN88METO0419788Binding with 3ogm CHAIN W 207 ALA, binding with 3ogm CHAIN W 206 ARG
3ogmN89PHEO0419789Binding with 3ogm CHAIN W 205 ARG, binding with ligand OGK, binding with 3ogm CHAIN W 204 ALA, binding with 3ogm CHAIN W 206 ARG
3ogmP121ARGO04197121Binding with ligand PO4
3ogmP301LEUO04197301Binding with 3ogm CHAIN X 209 LEU
3ogmP302TYRO04197302Binding with 3ogm CHAIN X 208 SER, binding with 3ogm CHAIN X 212 PHE
3ogmP326ARGO04197326Binding with 3ogm CHAIN X 212 PHE
3ogmP348ARGO04197348Binding with ligand OGK
3ogmP351ARGO04197351Binding with 3ogm CHAIN X 205 ARG, binding with 3ogm CHAIN X 203 ILE, binding with 3ogm CHAIN X 209 LEU
3ogmP386TYRO04197386Binding with ligand OGK
3ogmP409ARGO04197409Binding with ligand PO4, binding with ligand OGK
3ogmP444TYRO04197444Binding with ligand OGK
3ogmP469LEUO04197469Binding with ligand OGK
3ogmP496ARGO04197496Binding with 3ogm CHAIN X 204 ALA, binding with 3ogm CHAIN X 201 LEU, binding with ligand OGK, binding with 3ogm CHAIN X 202 PRO
3ogmP85ARGO0419785Binding with ligand PO4, binding with ligand OGK
3ogmP88METO0419788Binding with 3ogm CHAIN X 206 ARG, binding with 3ogm CHAIN X 207 ALA
3ogmP89PHEO0419789Binding with 3ogm CHAIN X 205 ARG, binding with 3ogm CHAIN X 204 ALA, binding with 3ogm CHAIN X 206 ARG, binding with ligand OGK
The PPI-HotSpotDB database and server was created by Chen Yao-Chi, Chen Yu-Hsien, Jon D Wright and Carmay Lim and is hosted at The Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan.